TRIS Promethazine Hydrochloride and Codeine Phosphate Oral Solution

Tris Pharma Promethazine With Codeine is a prescription oral solution containing promethazine hydrochloride and codeine phosphate. According to U.S. labeling, it is indicated for the temporary relief of cough and upper respiratory symptoms associated with allergy or the common cold in adults 18 years of age and older.

Each 5 mL contains 6.25 mg of promethazine hydrochloride and 10 mg of codeine phosphate. The product is an oral liquid formulation manufactured by Tris Pharma, Inc.

Because codeine is an opioid, this medication carries important risks, including respiratory depression, misuse, addiction, physical dependence, and overdose. Use this medicine only according to the prescribing information and directions provided by a qualified healthcare professional.

What Is TRIS Promethazine Hydrochloride and Codeine Phosphate Oral Solution?

TRIS Promethazine Hydrochloride and Codeine Phosphate Oral Solution combines two active ingredients: promethazine hydrochloride and codeine phosphate.

Promethazine is a phenothiazine with antihistamine properties. Codeine is an opioid that acts on the central nervous system and can suppress coughing.

Each 5 mL contains:

• Promethazine hydrochloride 6.25 mg

• Codeine phosphate 10 mg

The product is supplied as an oral solution for administration by mouth.

Tris Promethazine With Codeine Uses

Healthcare professionals may prescribe this medication for the temporary relief of cough and upper respiratory symptoms associated with allergy or the common cold in adults 18 years of age and older.

A healthcare professional should evaluate the patient’s symptoms, medical history, current medications, and potential risk factors before treatment.

Active Ingredients

The active ingredients are:

Promethazine hydrochloride: 6.25 mg per 5 mL

Codeine phosphate: 10 mg per 5 mL

Always verify the strength and formulation on the product label before use.

TRIS Promethazine With Codeine Product Features

TRIS Promethazine Hydrochloride and Codeine Phosphate Oral Solution provides a liquid dosage form that combines an antihistamine with an opioid cough suppressant.

Product characteristics include:

• Oral solution

• Promethazine hydrochloride 6.25 mg per 5 mL

• Codeine phosphate 10 mg per 5 mL

• Peach-mint flavor

• Prescription medication

• Manufactured by Tris Pharma, Inc.

Tris Pharma Promethazine With Codeine Side Effects

This medication can cause side effects. Possible effects include:

• Drowsiness

• Dizziness

• Nausea

• Vomiting

• Constipation

• Dry mouth

• Sedation

• Reduced alertness

• Blurred vision

Serious reactions can also occur. Seek emergency medical attention for severe breathing difficulties, extreme sedation, loss of consciousness, or other signs of a serious reaction or opioid overdose.

Important Safety Information

Codeine can cause serious or life-threatening respiratory depression.

The risk may increase when codeine is combined with alcohol, benzodiazepines, sedatives, sleeping medicines, or other central nervous system depressants.

The medication also carries warnings related to misuse, abuse, addiction, physical dependence, accidental ingestion, overdose, and neonatal opioid withdrawal syndrome.

Keep this medication securely stored and away from children. Never share prescription opioid medication with another person.

Promethazine With Codeine and Children

U.S. labeling contraindicates this medication in children younger than 12 years of age.

The labeled indication is for adults 18 years of age and older.

Codeine can cause serious or life-threatening respiratory problems in susceptible individuals. Follow the current product labeling and professional medical advice regarding age restrictions.

Promethazine With Codeine and Alcohol

Alcohol can increase the central nervous system depressant effects of promethazine and codeine.

Combining opioids with alcohol or other central nervous system depressants can increase the risk of profound sedation, respiratory depression, coma, and death.

Avoid alcohol while taking this medication unless a healthcare professional specifically advises otherwise.

Promethazine With Codeine Drug Interactions

This medication can interact with other medicines and substances.

Potentially important interactions include:

• Benzodiazepines

• Alcohol

• Opioids

• Sedatives

• Sleeping medicines

• Other central nervous system depressants

• Certain serotonergic medicines

• Medicines that affect CYP enzymes

Tell your doctor and pharmacist about all prescription medicines, over-the-counter products, supplements, and other substances you use.

How to Measure Promethazine With Codeine Oral Solution

Accurate measurement helps reduce medication errors.

Before using the product:

• Check the concentration printed on the container.

• Confirm the prescribed amount.

• Use an appropriate medication-measuring device.

• Measure the liquid carefully.

• Do not use an ordinary household spoon.

• Ask a pharmacist if you have questions about the prescribed amount.

The labeled concentration is 6.25 mg of promethazine hydrochloride and 10 mg of codeine phosphate per 5 mL.

Tris Pharma Promethazine With Codeine Dependence and Addiction

Codeine is an opioid and can cause physical dependence.

Repeated or inappropriate use can also lead to misuse, addiction, and overdose.

Patients who use opioid medication regularly should speak with a healthcare professional before stopping treatment. Sudden discontinuation after prolonged use may cause withdrawal symptoms.

Storage and Disposal

Store the medication according to the official product labeling.

Keep the container tightly closed and protect the medicine from unauthorized access.

Do not give the medication to another person, even if they have similar symptoms.

Follow the product label and applicable local requirements when disposing of unused medication.

When to Seek Emergency Medical Help

An opioid overdose can become life-threatening quickly.

Seek emergency medical attention if someone taking codeine:

• Has slow, shallow, or difficult breathing

• Cannot stay awake

• Cannot be awakened

• Loses consciousness

• Develops severe sedation

• Shows other signs of opioid overdose

Naloxone can reverse opioid overdose effects in many cases. If naloxone is available, use it according to its instructions and obtain emergency medical care immediately